While the Mayo Clinic website currently claims that puberty blockers simply “pause” puberty and “don’t cause permanent physical changes,” this recent study is just one of many that have sounded the alarm about the various harms of puberty blockers. In 2022, one study gained national attention after it found that putting children on puberty blockers causes irreversible harm to bone density.
The March study suggested that “abnormalities” from the data “raise a potential concern regarding the complete ‘reversibility’ and reproductive fitness of [spermatogonial stem cells]” for youth taking puberty blockers.
Researchers found that puberty blockers hurt the development of sperm production and could affect fertility when children grow up. They reported “mild-to-severe sex gland atrophy in puberty blocker-treated children.”
The study, which has not been peer-reviewed yet, looked at testicular samples for 87 patients under the age of 18. The study included 87 children total, with 16 boys who identified as girls and nine of whom took puberty blockers.
Two of the nine who were taking puberty blockers had abnormal features on their testicles that were observable from a physical examination.
The Mayo Clinic researchers noted that they began the study in a context where “the consequences” of puberty blockers for “juvenile testicular development and reproductive fitness” are “poorly understood.”
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